1,4-二氢吡啶衍生物中的分子内 C-H···O 氢键
Intramolecular C-H···O hydrogen bonding in 1,4-dihydropyridine derivatives.
机构信息
Latvian Institute of Organic Synthesis Aizkraukles 21 Street, Riga LV-1006, Latvia.
出版信息
Molecules. 2011 Sep 19;16(9):8041-52. doi: 10.3390/molecules16098041.
Abstract
The diastereotopy of the methylene protons at positions 2 and 6 in 1,4-dihydropiridine derivatives with various substituents has been investigated. NMR spectroscopy and quantum chemistry calculations show that the CH···O intramolecular hydrogen bond is one of the factors amplifying the chemical shift differences in the 1H-NMR spectra.
摘要
本文研究了具有不同取代基的 1,4-二氢吡啶衍生物中 2 位和 6 位亚甲基质子的非对映异构性。NMR 光谱和量子化学计算表明，CH···O 分子内氢键是放大 1H-NMR 光谱中化学位移差异的因素之一。
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