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具有 pH 激活的罗丹明内酰胺的双色介孔硅纳米粒子用于溶酶体酸度的比率型传感。

Dual colored mesoporous silica nanoparticles with pH activable rhodamine-lactam for ratiometric sensing of lysosomal acidity.

机构信息

Department of Chemical Biology, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, China.

出版信息

Chem Commun (Camb). 2011 Oct 28;47(40):11276-8. doi: 10.1039/c1cc14627k. Epub 2011 Sep 19.

DOI:10.1039/c1cc14627k
PMID:21931895
Abstract

Alteration of lysosome acidity has been implicated in many biological events ranging from apoptosis to cancer metastasis, etc. Mesoporous silica nanoparticles doped with acid activable rhodamine-lactam and fluorescein isothiocyanate (FITC) were developed for ratiometric sensing of lysosomal pH changes in live cells with flow cytometry.

摘要

溶酶体酸度的改变与许多生物学事件有关，从细胞凋亡到癌症转移等。本文制备了载酸激活型罗丹明内酰胺和异硫氰酸荧光素（FITC）的介孔硅纳米粒子，并用流式细胞术对活细胞内溶酶体 pH 值变化进行了比率检测。

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