Andrology and IVF Laboratories, University of Utah, Salt Lake City, UT 84108, USA.
J Cancer Res Clin Oncol. 2011 Dec;137(12):1729-38. doi: 10.1007/s00432-011-1056-3. Epub 2011 Sep 20.
Bladder cancer (BC) is one of the most widespread cancers afflicting men and women and also has major philosophical impact on health care worldwide. Despite elaborate characterization of the risk factors and treatment options, BC is still a major epidemiological problem worldwide and its incidence lingers to upswing each year. Over the last three decades, intravesical immunotherapy with the biological response modifier Mycobacterium bovis-Bacillus Calmette Guerin (BCG) has been established as the most effective adjuvant treatment for averting local recurrences and tumor progression following transurethral resection of non-muscle-invasive bladder cancer.
PUBMED database was searched for articles, and manuscripts were selected that provided data regarding the correlation of BCG therapy and its response with different cytokine gene variants.
It is not clear how Bacillus Calmette-Guerin (BCG) works to treat BC. It may stimulate an immune response or cause inflammation of the bladder wall that destroys cancer cells within the bladder. Lot of reports indicated the correlation of various cytokines with respect to BCG therapy in BC, but the exact mechanism is under debate.
Research continues to establish the most effectual strain of BCG and the best dosage schedule for the treatment for bladder cancer but, on the other hand, a very critical part of this therapy to find out the correlation of different cytokine with BCG therapy, which will give a better insights not only the mechanism but also a better therapeutic options.
膀胱癌（BC）是一种影响男性和女性的最常见癌症，也对全球医疗保健具有重大哲学影响。尽管对危险因素和治疗选择进行了详尽的描述，但 BC 仍然是全球范围内的一个主要流行病学问题，其发病率每年都在上升。在过去的三十年中，使用生物反应调节剂牛分枝杆菌-卡介苗（BCG）进行膀胱内免疫治疗已被确立为预防非肌肉浸润性膀胱癌经尿道切除术后局部复发和肿瘤进展的最有效辅助治疗方法。
在 PUBMED 数据库中搜索文章，并选择提供有关 BCG 治疗及其与不同细胞因子基因变异相关性的数据的手稿。
目前尚不清楚卡介苗（BCG）如何治疗 BC。它可能刺激免疫反应或引起膀胱壁炎症，从而破坏膀胱内的癌细胞。大量报告表明，各种细胞因子与 BC 中的 BCG 治疗相关，但确切的机制仍存在争议。
研究继续确定最有效的 BCG 菌株和治疗膀胱癌的最佳剂量方案，但另一方面，这种治疗的一个非常关键部分是找出不同细胞因子与 BCG 治疗的相关性，这不仅将提供对机制的更好理解，还将提供更好的治疗选择。
