Chemistry, University of Southampton, Highfield, Southampton, Hampshire, SO17 1BJ, UK.
Chemistry. 2011 Sep 19;17(39):10906-15. doi: 10.1002/chem.201101550.
Concise syntheses of the natural products cavicularin (ten steps) and riccardin C (seven steps) are reported. Key features of the new synthetic route are a convergent strategy to assemble acyclic precursors and a sequence of regioselective reduction and halogenation steps to facilitate Wittig macrocyclisation and transannular ring contraction reactions.
报告了天然产物 cavicularin（十步）和 riccardin C（七步）的简洁合成。新合成路线的关键特点是一种汇聚策略，用于组装无环前体，以及一系列区域选择性还原和卤化步骤，以促进 Wittig 大环化和反环缩合反应。
