Oliveira Marcelo José Andrade, de Almeida Laís Pinto, Wengerkievicz Annelise Correa, Siqueira Sheila Aparecida Coelho, Antonangelo Leila
Cytology Section, Clinical Laboratory, Pathology Department, Hospital das Clínicas, University of São Paulo Medical School, São Paulo-SP, Brazil.
Diagn Cytopathol. 2013 Apr;41(4):348-53. doi: 10.1002/dc.21771. Epub 2011 Sep 19.
Malignant small round cell tumors represent a diagnostic challenge for cytologists and pathologists. This case series describes four cases of unusual metastasis of small round cell tumors subtypes into body cavities generating effusions in which fluid cytological examination suggested the neuroendocrine origin of the tumors. Tumor diagnosis (Ewing sarcoma/primitive neuroectodermal tumor and desmoplastic small round cell tumors) were unknown at the cytological evaluation. We can highlight the importance of the accurate analyses of body fluids, both for early diagnosis of metastatic disease, and for the diagnosis of primary tumor when serous effusion is the first manifestation of the neoplasia.
恶性小圆细胞肿瘤对细胞学家和病理学家来说是一个诊断难题。本病例系列描述了4例小圆细胞肿瘤亚型罕见转移至体腔并产生积液的病例,其中液体细胞学检查提示肿瘤起源于神经内分泌。在细胞学评估时,肿瘤诊断(尤因肉瘤/原始神经外胚层肿瘤和促结缔组织增生性小圆细胞肿瘤)尚不明确。我们可以强调准确分析体液的重要性,这对于转移性疾病的早期诊断以及当浆液性积液是肿瘤的首发表现时对原发性肿瘤的诊断均具有重要意义。