Chang Wei-Jen, Hwang Pung-Pung
Institute of Cellular and Organismic Biology, Academia Sinica, Nankang, Taiwan.
Birth Defects Res C Embryo Today. 2011 Sep;93(3):205-14. doi: 10.1002/bdrc.20215.
Zebrafish epidermal ionocytes are analogous to mammalian kidney cells in terms of expression and function of ion transporters. In this review, we summarize current findings about the development of the zebrafish epidermis and demonstrate how the zebrafish regulate stress acclimation through induction of cell differentiation. In addition, cellular homologies between zebrafish epidermal ionocytes and mammalian kidney cells are presented to show the potential of zebrafish epidermis as an in vivo model to study the development and function of mammalian cells.
斑马鱼表皮离子细胞在离子转运蛋白的表达和功能方面类似于哺乳动物的肾细胞。在这篇综述中，我们总结了关于斑马鱼表皮发育的当前研究结果，并展示了斑马鱼如何通过诱导细胞分化来调节应激适应。此外，还介绍了斑马鱼表皮离子细胞与哺乳动物肾细胞之间的细胞同源性，以展示斑马鱼表皮作为研究哺乳动物细胞发育和功能的体内模型的潜力。
