Volkov V P
Klin Med (Mosk). 2011;89(4):27-30.
Ten most common and clinically significant pathological changes of ECG in schizophrenic patients with and without phenothiazine-induced cardiomyopathy (PCMP) at different stages of neuroleptic therapy are considered. A total of 46 men and 10 women were available for observation. The results of ECG studies in schizophrenics with PCMP and psychically healthy patients with DCMP were virtually identical. Dynamics of certain characteristics was shown to be of value for early diagnostics of phenothiazine cardiotoxic side-effects. These data confirm the advisability of regarding PCMP as a separate nosological entity in the group of seconfary cardiomyopathies.
研究了接受抗精神病药物治疗不同阶段的精神分裂症患者,有或无吩噻嗪所致心肌病(PCMP)的情况下,心电图最常见且具有临床意义的十种病理变化。共有46名男性和10名女性可供观察。患有PCMP的精神分裂症患者与患有药物性心肌病(DCMP)的心理健康患者的心电图研究结果基本相同。某些特征的动态变化对于吩噻嗪心脏毒性副作用的早期诊断具有价值。这些数据证实了将PCMP视为继发性心肌病组中一个独立病种的合理性。