Klin Med (Mosk). 2011;89(5):30-3.
A total of 830 autopsy protocols and medical histories of schizophrenic patients who died between 1952 and 2007 were analysed. Dilated cardiomyopathy (DCMP) occurred much more frequently than in the study of analogous material from the general population and patients with psychiatric disorders. The difference is attributed to the prolonged neuroleptic therapy with phenothiasine preparations in schizophrenics. This inference is confirmed by their significantly smaller heart mass compared with that in the period preceding this treatment. The frequency of DCMP in these patients significantly increased with duration of neuroleptic therapy. It is concluded that phenothiasine neuroleptics are etiological factors of DCMP. It is suggested to regard DCMP as an independent nosological form and call it phenothiasine-induced cardiomyopathy (FCMP).
对1952年至2007年间死亡的830例精神分裂症患者的尸检报告和病史进行了分析。与普通人群及精神疾病患者类似资料研究相比，扩张型心肌病（DCMP）的发生频率要高得多。这种差异归因于精神分裂症患者长期使用吩噻嗪类制剂进行抗精神病药物治疗。与该治疗前时期相比，他们的心脏重量明显较小，这证实了这一推断。这些患者中DCMP的发生率随抗精神病药物治疗时间的延长而显著增加。得出的结论是，吩噻嗪类抗精神病药物是DCMP的病因。建议将DCMP视为一种独立的病种形式，并称之为吩噻嗪诱导的心肌病（FCMP）。
