仿生不对称氢化：原位可再生的 Hantzsch 酯用于苯并恶嗪酮的不对称氢化。
Biomimetic asymmetric hydrogenation: in situ regenerable Hantzsch esters for asymmetric hydrogenation of benzoxazinones.
机构信息
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, P. R. China.
出版信息
J Am Chem Soc. 2011 Oct 19;133(41):16432-5. doi: 10.1021/ja208073w. Epub 2011 Sep 23.
PMID:21932832
Abstract
A catalytic amount of Hantzsch ester that could be regenerated in situ by Ru complexes under hydrogen gas has been employed in the biomimetic asymmetric hydrogenation of benzoxazinones with up to 99% ee in the presence of chiral phosphoric acid. The use of hydrogen gas as a reductant for the regeneration of Hantzsch esters makes this hydrogenation an ideal atom economic process.
摘要
使用了催化量的 Hantzsch 酯，该酯在氢气存在下可以被 Ru 配合物原位再生，在手性磷酸存在下，苯并恶嗪酮的仿生不对称氢化反应可以达到 99%的对映体过量。氢气作为 Hantzsch 酯再生的还原剂，使这种氢化反应成为一种理想的原子经济性过程。
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