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围产期心肌病的最新进展。

An update on peripartum cardiomyopathy.

作者信息

Dalzell Jonathan R, Jackson Colette E, Gardner Roy S

机构信息

Scottish Advanced Heart Failure Service, Golden Jubilee National Hospital, Glasgow, UK.

出版信息

Expert Rev Cardiovasc Ther. 2011 Sep;9(9):1155-60. doi: 10.1586/erc.11.121.

Abstract

Peripartum cardiomyopathy is a rare but potentially devastating complication of pregnancy. Although the definition of this condition has recently been revised by the Heart Failure Association of the European Society of Cardiology, the pathogenesis of peripartum cardiomyopathy is not well understood and relatively little is known about its incidence and prevalence. Hence, peripartum cardiomyopathy is often under-recognized in the clinical setting. A heightened awareness of this condition and its current management options is therefore warranted throughout primary and secondary care. The identification of the putative role of prolactin in the development and progression of this condition has been recently discovered, with preclinical work suggesting beneficial effects of prolactin antagonism. In this article, we review the literature regarding this condition including these recent advances.

摘要

围产期心肌病是一种罕见但可能具有毁灭性的妊娠并发症。尽管欧洲心脏病学会心力衰竭协会最近对这种疾病的定义进行了修订,但围产期心肌病的发病机制尚未完全明确,对其发病率和患病率也知之甚少。因此,围产期心肌病在临床环境中常常未得到充分认识。因此,在初级和二级医疗保健中,有必要提高对这种疾病及其当前治疗方案的认识。最近发现了催乳素在这种疾病的发生和发展中可能发挥的作用,临床前研究表明催乳素拮抗具有有益作用。在本文中,我们回顾了关于这种疾病的文献,包括这些最新进展。

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