Departments of Endocrinology, Institute of Cancer Research and Molecular Medicine, Trondheim, Norway.
Acta Obstet Gynecol Scand. 2012 Feb;91(2):232-6. doi: 10.1111/j.1600-0412.2011.01280.x. Epub 2011 Oct 17.
To assess possible associations between androgen, estrogen and insulin levels and blood pressure in pregnant women after term, compared with the effect of other well-known factors.
Cross-sectional retrospective study.
University Hospital, Trondheim region.
Four hundred and eighty-nine post-term women with uncomplicated pregnancies.
Blood pressure measurements and fasting serum samples drawn one week beyond the estimated day of delivery (defined as 41(+2) weeks).
Blood pressure, maternal age, body mass index, parity, smoking habits and serum levels of dehydroepiandrosterone sulfate, androstendione, free testosterone index, estradiol, estriol, progesterone, 17-hydroxy-progesterone and insulin.
In univariate linear regression analyses, body mass index, androstendione, free testosterone index and insulin were positively associated and parity was negatively associated with both systolic and diastolic blood pressure. In multivariate linear regression analyses, systolic blood pressure was positively associated with body mass index and free testosterone index, but negatively associated with parity and 17-hydroxy-progesterone levels, while diastolic blood pressure was positively associated with age and free testosterone index, but negatively associated with parity and 17-hydroxy-progesterone levels.
Testosterone may increase blood pressure in pregnant women, while 17-hydroxy-progesterone may have the opposite effect.
评估足月后孕妇的雄激素、雌激素和胰岛素水平与血压之间可能存在的关联，并与其他已知因素的影响进行比较。
回顾性横断面研究。
特隆赫姆地区大学医院。
489 名无并发症的足月妊娠孕妇。
在预计分娩日期（定义为 41(+2) 周）后一周内测量血压并抽取空腹血清样本。
血压、产妇年龄、体重指数、产次、吸烟习惯以及脱氢表雄酮硫酸酯、雄烯二酮、游离睾酮指数、雌二醇、雌三醇、孕酮、17-羟孕酮和胰岛素的血清水平。
在单变量线性回归分析中，体重指数、雄烯二酮、游离睾酮指数和胰岛素与收缩压和舒张压呈正相关，产次与收缩压和舒张压呈负相关。在多变量线性回归分析中，收缩压与体重指数和游离睾酮指数呈正相关，与产次和 17-羟孕酮水平呈负相关，而舒张压与年龄和游离睾酮指数呈正相关，与产次和 17-羟孕酮水平呈负相关。
睾酮可能会增加孕妇的血压，而 17-羟孕酮可能有相反的作用。
