Unit of Applied Clinical Research, Department of Cancer Research and Molecular Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Acta Obstet Gynecol Scand. 2010;89(1):87-94. doi: 10.3109/00016340903318006.
Breastfeeding depends on endocrine changes during pregnancy. The association between gestational hormones and lactation has been sparsely investigated. Previously, androgens were used for lactation inhibition. We investigated a possible association between second trimester maternal androgen levels and breastfeeding.
Prospective observational study.
University hospital setting. POPULATION. Women from a random sample of pregnancies (n = 63) and from a group with an increased risk for giving birth to a small-for-gestational age newborn (n = 118) were included. All participants had singleton pregnancies and one or two previous births.
Maternal androgen levels were measured in gestational week 25. The association with reported breastfeeding was explored by univariate and multivariate linear regression analyses. Analyses were adjusted for factors known to be associated with breastfeeding.
Breastfeeding at six weeks, three months, and six months postpartum.
In the random group, breastfeeding at three and six months was negatively associated with maternal testosterone, androstendione, and free testosterone index levels. After correction for maternal age, education and smoking, breastfeeding at both three and six months was negatively associated with the free testosterone index. In the group of women with an increased risk for giving birth to a small-for-gestational age newborn, breastfeeding at six weeks and three months was associated negatively with maternal dehydroepiandrosterone and this association persisted after correction for maternal age, education, and smoking.
Maternal androgen levels in mid-pregnancy are negatively associated with breastfeeding.
母乳喂养取决于妊娠期间的内分泌变化。妊娠激素与哺乳之间的关联尚未得到充分研究。先前，雄激素被用于抑制泌乳。我们研究了妊娠中期母体雄激素水平与母乳喂养之间的可能关联。
前瞻性观察性研究。
大学医院环境。
随机抽取的妊娠妇女（n=63）和有分娩小于胎龄儿风险增加的妇女（n=118）被纳入研究。所有参与者均为单胎妊娠且有一次或两次既往分娩史。
在妊娠 25 周时测量母体雄激素水平。通过单变量和多变量线性回归分析探索与报告母乳喂养的关联。分析调整了与母乳喂养相关的已知因素。
产后 6 周、3 个月和 6 个月的母乳喂养情况。
在随机组中，产后 3 个月和 6 个月的母乳喂养与母体睾酮、雄烯二酮和游离睾酮指数水平呈负相关。在调整了母体年龄、教育程度和吸烟状况后，产后 3 个月和 6 个月的母乳喂养仍与游离睾酮指数呈负相关。在有分娩小于胎龄儿风险增加的妇女组中，产后 6 周和 3 个月的母乳喂养与母体脱氢表雄酮呈负相关，且在调整了母体年龄、教育程度和吸烟状况后，这种关联仍然存在。
妊娠中期母体雄激素水平与母乳喂养呈负相关。
