Division of Hematology/Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Korea.
Oncology. 2011;81(1):55-62. doi: 10.1159/000331417. Epub 2011 Sep 16.
We evaluated whether skin changes and soft tissue infiltration patterns reflect breast cancer subtypes based on the breast hormonal receptor (HR) and human epidermal growth factor receptor 2 (HER2) status at the time of skin metastasis.
We retrospectively reviewed the patients' medical records with radiologic imaging studies.
The numbers of patients of each subtype were as follows: HR positive (HR+ve) 53 (42.4%), HER2 enriched 43 (34.4%), and triple negative (TN) 29 (23.2%). The presence of skin ulceration was found more commonly in the HR+ve group than in the others (57.1% for HR+ve vs. 25% for HER2 enriched vs. 15.4% for TN, p = 0.019). Erythematous infiltrations were shown predominantly in the TN group (19.0 vs. 54.2 vs. 84.6%, respectively, p < 0.000). On CT scans, soft tissue infiltration appeared to be more common in the HER2-enriched and TN groups than in the HR+ve group (24.5 vs. 41.9 vs. 48.3%, respectively, p = 0.013). Erythematous infiltrative lesions were more common in patients with epidermal growth factor receptor overexpression (p = 0.036).
The patterns of skin involvement including surrounding soft tissue infiltration may reflect breast cancer subtype. Prospective evaluation is necessary to confirm their influential effect on breast cancer subtypes.
我们评估了皮肤转移时的乳房激素受体（HR）和人表皮生长因子受体 2（HER2）状态是否反映了乳腺癌亚型，以及皮肤改变和软组织浸润模式。
我们回顾性地审查了有影像学研究的患者病历。
各亚型患者人数如下：HR 阳性（HR+ve）53 例（42.4%），HER2 丰富型 43 例（34.4%），三阴性（TN）29 例（23.2%）。HR+ve 组中皮肤溃疡的发生率高于其他组（57.1% vs. 25% vs. TN 组 15.4%，p=0.019）。红斑浸润主要见于 TN 组（19.0% vs. HER2 丰富组 54.2% vs. TN 组 84.6%，p<0.000）。在 CT 扫描中，HER2 丰富组和 TN 组的软组织浸润似乎比 HR+ve 组更常见（24.5% vs. 41.9% vs. 48.3%，p=0.013）。表皮生长因子受体过表达患者中红斑浸润性病变更为常见（p=0.036）。
包括周围软组织浸润在内的皮肤受累模式可能反映了乳腺癌亚型。需要前瞻性评估以确认它们对乳腺癌亚型的影响。
