Screening Group, Early Detection and Prevention Section, International Agency for Research on Cancer, Lyon, France.
Sex Transm Dis. 2011 Oct;38(10):902-6. doi: 10.1097/OLQ.0b013e318223be5f.
Little is known about the prevalence and determinants of human papillomavirus (HPV) infection in women from West India, although incidence of and mortality from cervical cancer is high.
Cervical specimens were collected, and questionnaires on lifestyle and reproductive factors were administered to 27,192 ever-married women aged 30 to 59 years living in a rural area of Maharashtra State, India. HPV-DNA status for high-risk HPV types was assessed using the second-generation hybrid-capture II assay.
The prevalence of HPV infection was 10.3% in this population of middle-aged women. High-risk HPV infection was associated with increasing age, low education level, manual work, early age at first sexual intercourse, and widowhood or separation.
Low socioeconomic status and vulnerable social groups such as widows and separated women are at a higher risk of HPV infection. This study demonstrates once again that HPV infection and subsequent cervical cancer are social diseases.
尽管宫颈癌的发病率和死亡率很高，但来自西印度的女性的人乳头瘤病毒 (HPV) 感染的流行情况和决定因素却鲜为人知。
采集了宫颈标本，并对马哈拉施特拉邦农村地区 27192 名年龄在 30 至 59 岁之间的已婚妇女进行了生活方式和生殖因素问卷调查。使用第二代杂交捕获 II 检测法评估高危型 HPV 类型的 HPV-DNA 状态。
在这群中年妇女中，HPV 感染的流行率为 10.3%。高危型 HPV 感染与年龄增长、教育水平低、体力劳动、初次性行为年龄早以及丧偶或分居有关。
低社会经济地位和寡妇、分居等弱势群体面临更高的 HPV 感染风险。这项研究再次证明，HPV 感染和随后的宫颈癌是社会疾病。
