Boucard Aurélie, Bétat Anne-Marie, Forster Roy, Simonnard Alain, Froget Guillaume
Centre International de Toxicologie (CIT), Evreux, France.
Curr Protoc Pharmacol. 2010 Dec;Chapter 10:Unit 10.12. doi: 10.1002/0471141755.ph1012s51.
This unit describes the functional observational battery (FOB), a behavioral screening procedure commonly used in safety pharmacology and toxicology studies to assess potentially adverse effects of test agents on the central nervous system. The battery includes general observations and the determination of reactivity to various stimuli. Also presented is the severity score index for analyzing individual measurements and evaluations over a range of endpoints. The severity score index can be used to identify, quantify, and describe the effects of compounds on neurological, autonomic, and behavioral functions.
本单元介绍了功能观察组合试验（FOB），这是一种行为筛选程序，常用于安全药理学和毒理学研究，以评估受试药物对中枢神经系统的潜在不良反应。该组合试验包括一般观察以及对各种刺激的反应性测定。还介绍了用于分析一系列终点的个体测量和评估的严重程度评分指数。严重程度评分指数可用于识别、量化和描述化合物对神经、自主和行为功能的影响。
