Kondrashin A V, Baranova A M, Morozova L F, Stepanova E V
Med Parazitol (Mosk). 2011 Jul-Sep(3):3-9.
The state-of-the-art of malaria elimination programs worldwide and the advances made in the past decade were analyzed and assessed. The factors contributing to or reducing the achievement of the final objective of malaria elimination--to interrupt the local transmission of the infection and to steadily maintain the achieved successes are given. Technical problems are defined at the final stages of a malaria elimination program. The problems include difficulties in identifying patients and asymptomatic parasite carriers due to the low level of malaria transmission and the absence of highly effective methods for detecting malaria parasites with low parasitemia, as well as mixed malaria infections requiring the use of different treatment regimens and antimalarial drugs. Large-scale uncontrolled population migration is noted to be of importance in spreading the infection in a malaria-free area. The solution of urgent tasks is to improve the existing methods and develop new ones for the detection and treatment of the infection and a package of antimalarial measures.
分析和评估了全球疟疾消除计划的现状以及过去十年取得的进展。阐述了有助于或阻碍实现疟疾消除最终目标（即中断感染的本地传播并持续保持已取得的成功）的因素。确定了疟疾消除计划最后阶段的技术问题。这些问题包括由于疟疾传播水平低以及缺乏检测低疟原虫血症的高效方法，难以识别患者和无症状寄生虫携带者，以及存在需要使用不同治疗方案和抗疟药物的混合疟疾感染情况。大规模不受控制的人口迁移被认为在无疟疾地区传播感染方面具有重要影响。当务之急是改进现有方法并开发新方法用于感染的检测和治疗以及一套抗疟措施。
