具有环磷酸腺苷依赖性蛋白激酶突变的小鼠淋巴瘤细胞
Mouse lymphoma cells with mutations of cyclic AMP-dependent protein kinase.
作者信息
Coffino P
出版信息
Natl Cancer Inst Monogr. 1978 May(48):377-80.
PMID:219362
Abstract
Because S49 cells are senstivie to killing by cyclic AMP (cAMP), mutants can be selected which have a variety of defects in their ability to generate or respond to cAMP. One class of mutants, that with deficiencies in cAMP-dependent protein kinase, has been extensively characterized genetically and biochemically.
摘要
由于S49细胞对环磷酸腺苷（cAMP）杀伤敏感，因此可以筛选出在产生或响应cAMP能力方面存在各种缺陷的突变体。一类突变体，即cAMP依赖性蛋白激酶存在缺陷的突变体，已经在遗传学和生物化学方面得到了广泛的表征。
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