环磷酸腺苷诱导淋巴瘤细胞死亡的机制
Mechanism of lymphoma cell death induced by cyclic AMP.
作者信息
Coffino P, Bourne H R, Tomkins G M
出版信息
Am J Pathol. 1975 Oct;81(1):199-204.
Abstract
A mouse lymphoma tissue culture line, S49, is killed by isoproterenol, choleratoxin, or prostaglandin E1, inducers of cyclic AMP (cAMP) in these cells, or by the analog dibutyryl (db) cAMP. Cell death follows arrest in the G1 phase of the cell cycle. Mutant subclones obtained by growing S49 with dbcAMP were resistant to killing. They were deficient in cAMP-dependent protein kinase. These results are discussed in relation to the possible physiologic role of cAMP-induced cell death in T-cell differentiation.
摘要
一种小鼠淋巴瘤组织培养细胞系S49，可被异丙肾上腺素、霍乱毒素或前列腺素E1（这些细胞中环磷酸腺苷（cAMP）的诱导剂）或类似物二丁酰（db）cAMP杀死。细胞死亡发生在细胞周期的G1期停滞之后。通过用dbcAMP培养S49获得的突变亚克隆对杀伤具有抗性。它们缺乏cAMP依赖性蛋白激酶。结合cAMP诱导的细胞死亡在T细胞分化中可能的生理作用对这些结果进行了讨论。
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