Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Lancet Neurol. 2011 Oct;10(10):909-21. doi: 10.1016/S1474-4422(11)70195-8.
Ischaemic stroke results from acute arterial occlusion leading to focal hypoperfusion. Thrombolysis is the only proven treatment. Advanced neuroimaging techniques allow a detailed assessment of the cerebral circulation in patients with acute stroke, and provide information about the status of collateral vessels and collateral blood flow, which could attenuate the effects of arterial occlusion. Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target. Several interventions that might augment collateral blood flow are being investigated.
缺血性脑卒中是由急性动脉闭塞导致的局部灌注不足引起的。溶栓治疗是唯一被证实有效的治疗方法。先进的神经影像学技术可以对急性脑卒中患者的脑循环进行详细评估，并提供有关侧支血管和侧支血流状态的信息，这可能会减轻动脉闭塞的影响。脑和血管成像显示，在大脑主要动脉闭塞数小时后，侧支血流仍能维持脑组织的功能，因此增加或维持侧支血流是一个潜在的治疗靶点。目前正在研究几种可能增加侧支血流的干预措施。
