Mary Ann and J. Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children's Memorial Hospital and Children's Memorial Research Center, Chicago, IL, USA.
Sleep Med. 2011 Oct;12(9):914-9. doi: 10.1016/j.sleep.2011.04.006. Epub 2011 Sep 21.
To investigate the association between sleep duration and insulin resistance in rural Chinese adults and examine whether any such associations are independent of adiposity.
This is a cross-sectional analysis of 854 men and 640 women aged 20 to 70 years from the Anqing Twin Cohort. The following measures were obtained for each subject: Body mass index (BMI) and percentage of trunk fat (%TF), fasting plasma glucose, homeostatic model assessment of insulin resistance index (HOMA-IR), self-reported sleep duration and measures of snoring and sleep disturbance from the Pittsburgh Sleep Quality Indices (PSQI) questionnaire were modified for a Chinese population. Multivariate linear regressions were applied to examine the association of sleep duration with HOMA-IR, with and without adjustment for adiposity variables, along with other relevant covariates.
In this sample of relatively lean rural Chinese adults, short sleep duration was associated with HOMA-IR in women but not in men. In women, short (≤ 7 h/night) sleep duration was associated with a higher HOMA-IR (p=0.003) compared with normal sleep duration (>7 to ≤ 8 h/night) after adjustment for all the covariates except adiposity. Further adjustment for BMI or %TF attenuated the sleep-HOMA-IR association, but the association remained significant upon adjustment for BMI (p=0.013); and upon adjustment for %TF (p=0.026). Long sleep duration (> 8 h/night) was not significantly associated with HOMA-IR.
In this rural Chinese cohort, short sleep duration is independently associated with increased insulin resistance among women only, even after adjusting for adiposity and other potential confounders.
探讨中国农村成年人睡眠时长与胰岛素抵抗之间的关系，并研究这些关联是否独立于肥胖。
这是一项横断面分析，共纳入来自安庆双胞胎队列的 854 名男性和 640 名 20 至 70 岁的女性。对每位受试者进行了以下测量：体重指数（BMI）和躯干脂肪百分比（%TF）、空腹血糖、稳态模型评估的胰岛素抵抗指数（HOMA-IR）、自我报告的睡眠时间以及匹兹堡睡眠质量指数（PSQI）问卷中针对中国人进行了修改的打鼾和睡眠障碍测量。采用多元线性回归分析，在不调整和调整肥胖变量的情况下，分别研究睡眠时长与 HOMA-IR 的关联，同时还研究了其他相关协变量。
在这个相对较瘦的中国农村成年人样本中，短睡眠时间与女性的 HOMA-IR 相关，但与男性无关。在女性中，与正常睡眠时间（>7 至≤8 小时/晚）相比，短睡眠时间（≤7 小时/晚）与更高的 HOMA-IR 相关（p=0.003），在调整了所有协变量（除肥胖外）后。进一步调整 BMI 或 %TF 减弱了睡眠-HOMA-IR 关联，但在调整 BMI 后该关联仍然显著（p=0.013）；在调整 %TF 后也仍然显著（p=0.026）。长睡眠时间（>8 小时/晚）与 HOMA-IR 无显著相关性。
在这个农村中国队列中，短睡眠时间与女性胰岛素抵抗增加独立相关，即使在调整了肥胖和其他潜在混杂因素后也是如此。
