美国成年人室内过敏原暴露与睡眠健康的关系。

Indoor allergen exposure in relation to sleep health among US adults.

作者信息

Murkey Jamie A, Wilkerson Jesse, Salo Paivi M, Thorne Peter S, Zeldin Darryl C, Jackson Chandra L

机构信息

Epidemiology Branch, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC.

DLH, LLC, Bethesda, Md.

出版信息

J Allergy Clin Immunol Glob. 2025 Feb 18;4(2):100441. doi: 10.1016/j.jacig.2025.100441. eCollection 2025 May.

DOI:10.1016/j.jacig.2025.100441

PMID:40201037

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11978379/

Abstract

BACKGROUND

Common indoor allergens can accumulate within the sleep microenvironment (eg, bedding) and may contribute to poor sleep health.

OBJECTIVE

We sought to examine bedroom allergen exposure in relation to multiple sleep dimensions among US adults.

METHODS

Data for this study (N = 3399) were collected during the 2005 to 2006 National Health and Nutrition Examination Survey. Concentrations of 8 bedroom allergens were assessed and classified as elevated when levels exceeded 75th/90th percentile thresholds. Self-reported sleep measures included having trouble sleeping, any sleep disorder, snoring, and sleep medication use. Adjusting for confounders, we used Poisson regression to estimate associations between bedroom allergen exposures and sleep dimensions overall and by race/ethnicity, sex/gender, and socioeconomic status.

RESULTS

Among adults, elevated pet allergen exposure was the most prevalent (41.2%). Elevated pest allergen exposure was associated with a lower likelihood of a reported sleep disorder diagnosis (prevalence ratio [PR], 0.68; 95% CI, 0.51-0.90). For Hispanic/Latino participants, elevated pet allergen exposure was associated with having trouble sleeping (PR, 1.74; 95% CI, 1.02-2.96) and frequent snoring (PR, 1.31; 95% CI, 1.01-1.70). Elevated fungal allergen exposure was associated with any sleep disorder diagnosis among participants with moderate socioeconomic status (PR, 3.31; 95% CI, 1.21-9.10) and a higher prevalence of sleep medication use for Hispanic/Latino participants (PR, 5.72; 95% CI, 2.53-12.90; < .01). Elevated exposures to pet (PR, 1.93; 95% CI, 1.12-3.32) and fungal (PR, 1.71; 95% CI, 1.05-2.80) allergens were also associated with being diagnosed with any sleep disorder among women.

CONCLUSIONS

In a nationally representative sample of US adults, exposure to elevated levels of bedroom allergens was associated with poor sleep health, and the magnitude of the associations was generally the strongest among minoritized racial/ethnic groups and women.

摘要

背景

常见的室内过敏原可在睡眠微环境（如床上用品）中积聚，并可能导致睡眠健康不佳。

目的

我们试图研究美国成年人卧室过敏原暴露与多种睡眠维度之间的关系。

方法

本研究的数据（N = 3399）收集于2005年至2006年的美国国家健康和营养检查调查。评估了8种卧室过敏原的浓度，当水平超过第75/90百分位数阈值时被归类为升高。自我报告的睡眠指标包括睡眠困难、任何睡眠障碍、打鼾和使用睡眠药物。在调整混杂因素后，我们使用泊松回归来估计卧室过敏原暴露与总体睡眠维度以及按种族/族裔、性别和社会经济地位划分的睡眠维度之间的关联。

结果

在成年人中，宠物过敏原暴露升高最为普遍（41.2%）。害虫过敏原暴露升高与报告的睡眠障碍诊断可能性较低相关（患病率比值[PR]，0.68；95%置信区间，0.51 - 0.90）。对于西班牙裔/拉丁裔参与者，宠物过敏原暴露升高与睡眠困难（PR，1.74；95%置信区间，1.02 - 2.96）和频繁打鼾（PR，1.31；95%置信区间，1.01 - 1.70）相关。真菌过敏原暴露升高与社会经济地位中等的参与者的任何睡眠障碍诊断相关（PR，3.31；95%置信区间，1.21 - 9.10），并且西班牙裔/拉丁裔参与者使用睡眠药物的患病率更高（PR，5.72；95%置信区间，2.53 - 12.90；P <.01）。宠物（PR，1.93；95%置信区间，1.12 - 3.32）和真菌（PR，1.71；95%置信区间，1.05 - 2.80）过敏原暴露升高也与女性被诊断患有任何睡眠障碍相关。