威廉姆斯综合征患儿的睡眠。
Sleep in children with Williams Syndrome.
机构信息
Sleep Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
出版信息
Sleep Med. 2011 Oct;12(9):892-7. doi: 10.1016/j.sleep.2011.05.003. Epub 2011 Sep 21.
OBJECTIVE
To analyze sleep in children with Williams Syndrome (WS) compared to normal healthy controls in order to determine whether particular sleep features are characteristic of WS, and to explore associations between disturbed sleep and behavior.
METHODS
Thirty-five children with genetically-confirmed WS and 35 matched controls underwent overnight polysomnography and performance testing in the Sleep Center at the Children's Hospital of Philadelphia. Parents completed questionnaires regarding the subjects' sleep and behavior.
RESULTS
WS subjects had significantly different sleep than controls, with decreased sleep efficiency, increased respiratory-related arousals and increased slow wave sleep on overnight polysomnography. WS subjects were also noted to have more difficulty falling asleep, with greater restlessness and more arousals from sleep than controls. Fifty-two percent of WS subjects had features of attention deficit-hyperactivity disorder.
CONCLUSION
Children with WS had significantly different sleep than controls in our sample. These differences demonstrated in our study may reflect genetic influences on sleep.
目的
分析威廉姆斯综合征（WS）患儿的睡眠情况，并与正常健康对照组进行比较，以确定是否存在特定的睡眠特征与 WS 相关，并探讨睡眠障碍与行为之间的关联。
方法
35 名经基因确认的 WS 患儿和 35 名匹配的对照组在费城儿童医院的睡眠中心进行了整夜多导睡眠图和行为测试。家长们完成了关于孩子睡眠和行为的调查问卷。
结果
WS 组患儿的睡眠与对照组有显著差异，表现为睡眠效率降低、呼吸相关觉醒增加和慢波睡眠增加。WS 组患儿入睡也更加困难，表现为更明显的不安和更多的睡眠觉醒。52%的 WS 患儿存在注意缺陷多动障碍的特征。
结论
在我们的样本中，WS 患儿的睡眠与对照组有显著差异。我们研究中表现出的这些差异可能反映了遗传对睡眠的影响。
Zotero 插件