Zhang Jin-Shun, Ye Li-Ping, Zhang Jin-Lan, Wang Cai-Ya, Chen Ji-Ya
Taizhou Hospital, Linhai, China.
Hepatogastroenterology. 2011 Sep-Oct;58(110-111):1618-21. doi: 10.5754/hge11081. Epub 2011 Jul 15.
BACKGROUND/AIMS: Capsule endoscopy (CE) reaches the cecum in about 80% of cases. Decreasing the gastric transit time (GTT) may increase the complete examination rate (CER).
Patients (n=177) were prospectively randomized into 2 groups: the control group (n=88) and the intramuscular injection with metoclopramide (IIM) group (n=89). The OMOM CE system, which has the function of real-time monitoring, was used. The patients were injected with metoclopramide 15 minutes before swallowing the CE in the IIM group. The CE would be sent into the duodenum by gastroscopy if the GTT reached 120 minutes in the two groups.
No significant difference was noted between the two groups. Of the 169 cases without gastroscopic help, the mean GTT was shorter in the IIM group (n=87) than the control group (n=82) (p=0.002). But the CER was similar. Of 135 cases without gastroscopic help but reached the cecum, the mean GTT was shorter in the IIM group (n=71) than the control group (n=64) (p=0.015). But the mean small bowel transit time (SBTT) was similar.
Intramuscular injection of metoclopramide decreases the gastric transit time, but it does not change the SBTT or CER of capsule endoscopy in our study.
背景/目的：胶囊内镜检查（CE）在约80%的病例中可到达盲肠。缩短胃传输时间（GTT）可能会提高完整检查率（CER）。
将177例患者前瞻性随机分为2组：对照组（n = 88）和甲氧氯普胺肌肉注射组（IIM组，n = 89）。使用具有实时监测功能的OMOM CE系统。IIM组患者在吞咽胶囊内镜前15分钟注射甲氧氯普胺。如果两组的GTT达到120分钟，则通过胃镜将胶囊内镜送入十二指肠。
两组之间未观察到显著差异。在169例未借助胃镜的病例中，IIM组（n = 87）的平均GTT比对照组（n = 82）短（p = 0.002）。但CER相似。在135例未借助胃镜但到达盲肠的病例中，IIM组（n = 71）的平均GTT比对照组（n = 64）短（p = 0.015）。但平均小肠传输时间（SBTT）相似。
在我们的研究中，肌肉注射甲氧氯普胺可缩短胃传输时间，但不会改变胶囊内镜检查的SBTT或CER。
