Miyazaki R M, Muraki N, Kohno N, Kamei K, Kunitomo F, Kuriyama T, Kanno H, Yamagishi F, Kikuchi N
Department of Chest Medicine, Institute of Pulmonary Cancer Research, School of Medicine, Chiba University.
Jpn J Antibiot. 1990 Feb;43(2):326-36.
The usefulness of cefteram pivoxil (CFTM-PI) was evaluated in 99 cases with respiratory tract infections: 32 cases with acute bronchitis, 51 cases with infectious exacerbations of chronic respiratory diseases and 16 cases with pneumonia. 1. The clinical efficacies included marked improvement in 27 cases, improvement in 51 cases, moderate improvement in 9 cases, no change in 10 cases and deterioration in 2 cases. The improvement rate was 78.8%. 2. Overall effects were excellent in 12 cases, good in 9 cases and fair in 5 cases. There was no case in which efficacy was not observed and the efficacy rate was 80.8%. 3. Bacteriological effects were classified according to the causative organisms. Eradication rate was 80.8% (21 of 26 strains), indicating an excellent antibacterial action of CFTM-PI. In particular, MICs of cefteram were below 0.05 microgram/ml against all 10 strains of Haemophilus influenzae regardless of beta-lactamase production even with an inoculum of 10(8) or 10(6) cells/ml. 4. Side effects rarely occurred and included a slight gastrointestinal irritation in 4 of 99 cases (4%). Two cases which had abnormal elevations of GOT and GPT had abnormal values prior to administration of CFTM-PI. The elevations were slight and it was possible to continue administration. The GOT and GPT values were improved after the end of administration. The above results indicate the usefulness of CFTM-PI in acute respiratory infections and infectious exacerbation of chronic respiratory diseases.
对99例呼吸道感染患者评估了头孢特仑新戊酯（CFTM-PI）的疗效：其中急性支气管炎32例，慢性呼吸道疾病感染加重期51例，肺炎16例。1. 临床疗效：显著改善27例，改善51例，中度改善9例，无变化10例，恶化2例。改善率为78.8%。2. 总体效果：优12例，良9例，中5例。无无效病例，有效率为80.8%。3. 细菌学效果根据病原体分类。根除率为80.8%（26株中的21株），表明CFTM-PI具有优异的抗菌作用。特别是，无论β-内酰胺酶产生情况如何，头孢特仑对所有10株流感嗜血杆菌的最低抑菌浓度均低于0.05微克/毫升，接种量为10(8)或10(6)个细胞/毫升。4. 副作用很少发生，99例中有4例（4%）出现轻微胃肠道刺激。2例谷草转氨酶（GOT）和谷丙转氨酶（GPT）异常升高的患者在使用CFTM-PI之前就有异常值。升高程度轻微，可以继续用药。用药结束后GOT和GPT值有所改善。上述结果表明CFTM-PI在急性呼吸道感染和慢性呼吸道疾病感染加重期的有效性。
