Petrenko V A, Kuz'micheva G A, Tat'kov S I, Krasnoborov I I, Pozdniakov P I, Il'ichev A A, Baturina I A, Khomov V V
Mol Biol (Mosk). 1990 Mar-Apr;24(2):460-6.
The mutation system has been suggested in an effort to test insertion and deletion mutants by changing the Lac-phenotype of bacterial colonies transformed by mutant DNA. This system also makes possible to determine heterozygotes and homozygotes among the mutants. The yield of mutants in shown to depend on the structure of the DNA heteroduplex region. The yield of deletion mutants is greater than that of insertion mutants. Heterozygotes prevail in mutant colonies (greater than 90%).
已经提出了突变系统，以便通过改变由突变DNA转化的细菌菌落的乳糖表型来测试插入和缺失突变体。该系统还能够确定突变体中的杂合子和纯合子。结果表明，突变体的产量取决于DNA异源双链区域的结构。缺失突变体的产量高于插入突变体。杂合子在突变菌落中占主导地位（超过90%）。
