维生素 D 在哮喘肺中的作用机制。
Mechanism of action of vitamin D in the asthmatic lung.
机构信息
Division of Emergency Medicine, Children's National Medical Center, Washington, DC, USA.
出版信息
J Investig Med. 2011 Dec;59(8):1200-2. doi: 10.2130/JIM.0b013e31823279f0.
Abstract
Vitamin D, or 1,25-dihydroxy vitamin D (1,25[OH]D), in its activated form, has long been recognized as a critical mediator in bone health. New research has identified 1,25(OH)D as also vital for respiratory health. Owing to its intrinsic anti-inflammatory properties, 1,25(OH)D may be very important in people with asthma. This review article seeks to evaluate the current literature to delineate the potential mechanisms of action by which 1,25(OH)D affects asthma. We summarize the evidence that 1,25(OH)D has receptors in multiple lung cell types and acts to abrogate asthma by several mechanisms: promoting lung immunity, decreasing inflammation, slowing cell cycling, reducing hyperplasia, and enhancing the effects of exogenous steroids. Put together, there is compelling evidence for the role of vitamin D in asthma.
摘要
维生素 D，或 1,25-二羟维生素 D（1,25[OH]D），以其激活形式，长期以来一直被认为是骨骼健康的关键介质。新的研究已经确定 1,25(OH)D 对呼吸健康也至关重要。由于其内在的抗炎特性，1,25(OH)D 在哮喘患者中可能非常重要。本文旨在评估目前的文献，以阐明 1,25(OH)D 影响哮喘的潜在作用机制。我们总结了证据，证明 1,25(OH)D 在多种肺细胞类型中都有受体，并通过多种机制来消除哮喘：促进肺免疫、减少炎症、减缓细胞周期、减少增生、增强外源性类固醇的作用。总的来说，维生素 D 在哮喘中的作用有充分的证据。
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本文引用的文献
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