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系膜细胞在肾小球病理学中的作用。

The role of mesangial cells in glomerular pathology.

作者信息

Hawkins N J, Wakefield D, Charlesworth J A

机构信息

School of Pathology, University of New South Wales, Sydney.

出版信息

Pathology. 1990 Jan;22(1):24-32. doi: 10.3109/00313029009061422.

DOI:10.3109/00313029009061422
PMID:2194156
Abstract

The glomerular mesangial cell has become increasingly recognized as a multifunctional cell capable of mediating glomerular disease. This article reviews recent findings regarding the biology of these cells, and the relevance that these findings may have for our understanding of glomerular pathology.

摘要

肾小球系膜细胞越来越被认为是一种能够介导肾小球疾病的多功能细胞。本文综述了有关这些细胞生物学的最新发现,以及这些发现对于我们理解肾小球病理学可能具有的相关性。

相似文献

1
The role of mesangial cells in glomerular pathology.系膜细胞在肾小球病理学中的作用。
Pathology. 1990 Jan;22(1):24-32. doi: 10.3109/00313029009061422.
2
Functional properties of glomerular cells in culture.培养的肾小球细胞的功能特性
Miner Electrolyte Metab. 1986;12(1):25-31.
3
Effect of platelet-activating factor and serum-treated zymosan on prostaglandin E2 synthesis, arachidonic acid release, and contraction of cultured rat mesangial cells.血小板活化因子和血清处理的酵母聚糖对培养的大鼠系膜细胞前列腺素E2合成、花生四烯酸释放及收缩的影响
J Clin Invest. 1984 Apr;73(4):1227-31. doi: 10.1172/JCI111309.
4
Platelet-derived growth factor and fibroblast growth factor differentially regulate interleukin 1beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells.血小板衍生生长因子和成纤维细胞生长因子对大鼠肾系膜细胞中白细胞介素1β和cAMP诱导的一氧化氮合酶表达有不同的调节作用。
J Clin Invest. 1997 Dec 1;100(11):2800-9. doi: 10.1172/JCI119827.
5
A role for platelet-activating factor in endothelin-1-induced rat mesangial cell proliferation.血小板活化因子在内皮素-1诱导的大鼠系膜细胞增殖中的作用。
Eur J Pharmacol. 1993 Oct 26;243(3):235-40. doi: 10.1016/0014-2999(93)90180-p.
6
SPARC is expressed by mesangial cells in experimental mesangial proliferative nephritis and inhibits platelet-derived-growth-factor-medicated mesangial cell proliferation in vitro.在实验性系膜增生性肾炎中,系膜细胞表达SPARC,并在体外抑制血小板衍生生长因子介导的系膜细胞增殖。
Am J Pathol. 1996 Apr;148(4):1153-67.
7
Interleukin 4 downregulates cell growth and prostaglandin release of human mesangial cells.白细胞介素4可下调人系膜细胞的细胞生长和前列腺素释放。
Biochem Biophys Res Commun. 1993 Dec 15;197(2):486-93. doi: 10.1006/bbrc.1993.2505.
8
Cultured human glomerular mesangial cells express the C5a receptor.
Kidney Int. 1998 Nov;54(5):1542-9. doi: 10.1046/j.1523-1755.1998.00155.x.
9
Production of interleukin-1 by mononuclear leukocytes and mesangial cells in experimental nephrotoxic nephritis.实验性肾毒性肾炎中单核白细胞和系膜细胞白细胞介素-1的产生。
Nephron. 1991;58(1):112-3. doi: 10.1159/000186390.
10
Thrombospondin peptides are potent inhibitors of mesangial and glomerular endothelial cell proliferation in vitro and in vivo.血小板反应蛋白肽在体外和体内都是系膜细胞和肾小球内皮细胞增殖的有效抑制剂。
Kidney Int. 1999 Jun;55(6):2236-49. doi: 10.1046/j.1523-1755.1999.00459.x.

引用本文的文献

1
miR-744 enhances type I interferon signaling pathway by targeting PTP1B in primary human renal mesangial cells.在原代人肾系膜细胞中,miR-744通过靶向蛋白酪氨酸磷酸酶1B(PTP1B)增强I型干扰素信号通路。
Sci Rep. 2015 Aug 11;5:12987. doi: 10.1038/srep12987.
2
Gremlin induces cell proliferation and extra cellular matrix accumulation in mouse mesangial cells exposed to high glucose via the ERK1/2 pathway.格林瘤通过 ERK1/2 通路诱导高糖诱导的小鼠系膜细胞增殖和细胞外基质积累。
BMC Nephrol. 2013 Feb 11;14:33. doi: 10.1186/1471-2369-14-33.
3
Effects of dexamethasone and transforming growth factor-beta 2 on group II phospholipase A2 mRNA and activity levels in interleukin 1 beta- and forskolin-stimulated mesangial cells.
地塞米松和转化生长因子-β2对白细胞介素1β和福斯高林刺激的系膜细胞中Ⅱ型磷脂酶A2 mRNA及活性水平的影响
Biochem J. 1996 Apr 15;315 ( Pt 2)(Pt 2):435-41. doi: 10.1042/bj3150435.
4
C3 and C4 gene expression and interferon-gamma-mediated regulation in human glomerular mesangial cells.人肾小球系膜细胞中C3和C4基因表达及干扰素-γ介导的调节
Clin Exp Immunol. 1993 Sep;93(3):411-7. doi: 10.1111/j.1365-2249.1993.tb08193.x.
5
Detection and cellular localization of human C4 gene expression in the renal tubular epithelial cells and other extrahepatic epithelial sources.人C4基因在肾小管上皮细胞及其他肝外上皮来源中的表达检测与细胞定位。
Am J Pathol. 1991 Oct;139(4):717-24.