森替酰胺，一种来自嗜线虫致病杆菌DSM 16338T的N-甲酰化环缩肽。
Szentiamide, an N-formylated cyclic depsipeptide from Xenorhabdus szentirmaii DSM 16338T.
作者信息
Ohlendorf Birgit, Simon Sven, Wiese Jutta, Imhoff Johannes F
机构信息
Kieler Wirkstoff-Zentrum (KiWiZ) at the Leibniz Institute of Marine Sciences (IFM-GEOMAR), Am Kiel-Kanal 44, D-24106 Kiel, Germany.
出版信息
Nat Prod Commun. 2011 Sep;6(9):1247-50.
Szentiamide (1) a new cyclic hexadepsipeptide was isolated from the culture broth of the entomopathogenic bacterium Xenorhabdus szentirmaii DSM 16338T. The structure was elucidated by analysis of one- and two-dimensional NMR spectra and high resolution mass spectrometry. The amino acids were determined to be D-leucine, L-threonine, D-phenylalanine, D-valine, L-tyrosine and L-tryptophane after hydrolysis and derivatization with D-FDVA [Nalpha-(2,4-dinitro-5-fluorophenyl)-D-valinamide].
从昆虫病原细菌斯氏 Xenorhabdus szentirmaii DSM 16338T 的培养液中分离出一种新的环状六聚脂肽——森替酰胺（1）。通过一维和二维核磁共振光谱分析及高分辨率质谱法阐明了其结构。水解并用 D-FDVA [Nα-(2,4-二硝基-5-氟苯基)-D-缬氨酰胺]衍生化后，确定氨基酸为 D-亮氨酸、L-苏氨酸、D-苯丙氨酸、D-缬氨酸、L-酪氨酸和 L-色氨酸。
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