Moving out: from sterol transport to drug resistance - the ABCG subfamily of efflux pumps.
作者信息
Moitra Karobi, Silverton Latoya, Limpert Katy, Im Kate, Dean Michael
机构信息
National Cancer Institute, Frederick, MD, USA.
出版信息
Drug Metabol Drug Interact. 2011;26(3):105-11. doi: 10.1515/DMDI.2011.015. Epub 2011 Sep 27.
Abstract
The ATP binding cassette (ABC) proteins are typically ATP-driven transmembrane pumps that have been evolutionarily conserved from bacteria to humans. In humans these transporters are subdivided into seven subfamilies, ranging from A to G. The ABCG subfamily of transporters is the primary focus of this review. This subfamily of proteins has been conserved throughout evolution and plays a central role in several cellular processes, such as sterol homeostasis and multidrug resistance. Functional polymorphisms/mutations in some of these G-subfamily transporters have clinical consequences in humans.
摘要
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