Kotlyarov Stanislav, Kotlyarova Anna
Department of Nursing, Ryazan State Medical University, 390026 Ryazan, Russia.
Department of Pharmacy Management and Economics, Ryazan State Medical University, 390026 Ryazan, Russia.
Biology (Basel). 2024 Dec 25;14(1):8. doi: 10.3390/biology14010008.
ATP-binding cassette (ABC) transporters are a large family of proteins that transport various substances across cell membranes using energy from ATP hydrolysis. ATP-binding cassette sub-family G member 1 (ABCG1) is a member of the ABCG subfamily of transporters and performs many important functions, such as the export of cholesterol and some other lipids across the membranes of various cells. Cholesterol transport is the mechanism that links metabolism and the innate immune system. Due to its lipid transport function, ABCG1 may contribute to the prevention of atherosclerosis and is involved in the functioning of the lung, pancreas, and other organs and systems. However, the full clinical significance of ABCG1 is still unknown and is a promising area for future research.
ATP结合盒（ABC）转运蛋白是一大类蛋白质家族，它们利用ATP水解产生的能量跨细胞膜转运各种物质。ATP结合盒亚家族G成员1（ABCG1）是ABC转运蛋白亚家族G的成员，具有许多重要功能，例如将胆固醇和其他一些脂质跨各种细胞膜输出。胆固醇转运是连接代谢与先天免疫系统的机制。由于其脂质转运功能，ABCG1可能有助于预防动脉粥样硬化，并参与肺、胰腺及其他器官和系统的功能。然而，ABCG1的全部临床意义仍不明确，是未来研究的一个有前景的领域。
