Department of Stomatology, Ningxia Medical University Affiliated Hospital, Yinchuan, Ningxia Province, People's Republic of China.
DNA Cell Biol. 2012 Apr;31(4):520-3. doi: 10.1089/dna.2011.1310. Epub 2011 Sep 23.
Basic fibroblast growth factor (FGF2) is a well-known endothelial mitogen that regulates endothelial cell proliferation, migration, differentiation, and survival. In the present study, we investigated the levels of FGF2 and fibroblastic growth factor receptor 1 (FGFR1) in saliva and serum of patients with salivary gland tumors. Saliva and serum samples were collected from 43 patients with salivary gland tumors and 40 healthy volunteers. The FGF2 and FGFR1 concentrations in saliva and serum samples were measured by enzyme-linked immunosorbent assay. We found that the levels of FGF2 and FGFR1 in saliva and serum from patients with salivary gland tumors were significantly higher than those from healthy control subjects. These results suggest that salivary FGF2 and FGFR1 can be used as potential biomarkers in the diagnosis of salivary gland tumors.
碱性成纤维细胞生长因子（FGF2）是一种众所周知的内皮细胞有丝分裂原，可调节内皮细胞的增殖、迁移、分化和存活。本研究探讨了唾液和血清中唾液腺肿瘤患者的 FGF2 和成纤维细胞生长因子受体 1（FGFR1）水平。收集了 43 例唾液腺肿瘤患者和 40 例健康志愿者的唾液和血清样本。通过酶联免疫吸附试验测量唾液和血清样本中的 FGF2 和 FGFR1 浓度。结果发现，唾液腺肿瘤患者唾液和血清中的 FGF2 和 FGFR1 水平明显高于健康对照组。这些结果表明，唾液中的 FGF2 和 FGFR1 可作为唾液腺肿瘤诊断的潜在生物标志物。
