Myoken Y, Myoken Y, Okamoto T, Sato J D, Kan M, McKeehan W L, Nakahara M, Takada K
Department of Oral and Maxillofacial Surgery I, Hiroshima University School of Dentistry, Japan.
J Pathol. 1996 Apr;178(4):429-36. doi: 10.1002/(SICI)1096-9896(199604)178:4<429::AID-PATH495>3.0.CO;2-1.
Fibroblast growth factor-1 (FGF-1) and FGF-2 are broad spectrum mitogens. The expression of FGF-1, FGF-2, and their receptor, FGF receptor-1 (FGFR-1), was examined in malignant salivary gland tumours and normal salivary glands, using immunohistochemical methods. In seven cases of adenoid cystic carcinoma (ACC), both duct-like cells and modified myoepithelial cells were apparently immunopositive for FGF-1, FGF-2, and FGFR-1. In five cases of mucoepidermoid carcinoma (MC), all three types of tumour cells including epidermoid cells, and intermediate cells expressed immunoreactive FGF-1, FGF-2, and FGFR-1. In these malignant salivary gland tumours, increased expression of FGFR-1 correlated with the intensity of both FGF-1 and FGF-2 immunoreactivity. In contrast to malignant salivary gland tumours, eight cases of normal salivary gland showed negative immunostaining for FGF-1, FGF-2, and FGFR-1 while four cases were weakly immunoreactive for FGF and its receptor. These results demonstrate that malignant salivary gland tumours overexpress FGF-1, FGF-2, and FGFR-1 compared with normal salivary glands and suggest that these growth factors may play an important role in facilitating neoplastic progression in human salivary glands.
成纤维细胞生长因子-1（FGF-1）和FGF-2是广谱促细胞分裂剂。采用免疫组织化学方法，检测了恶性涎腺肿瘤和正常涎腺中FGF-1、FGF-2及其受体FGF受体-1（FGFR-1）的表达情况。在7例腺样囊性癌（ACC）中，导管样细胞和改良肌上皮细胞对FGF-1、FGF-2和FGFR-1均呈明显免疫阳性。在5例黏液表皮样癌（MC）中，包括表皮样细胞和中间细胞在内的所有三种肿瘤细胞均表达免疫反应性FGF-1、FGF-2和FGFR-1。在这些恶性涎腺肿瘤中，FGFR-1表达增加与FGF-1和FGF-2免疫反应强度相关。与恶性涎腺肿瘤不同，8例正常涎腺对FGF-1、FGF-2和FGFR-1呈免疫染色阴性，而4例对FGF及其受体呈弱阳性反应。这些结果表明，与正常涎腺相比，恶性涎腺肿瘤中FGF-1、FGF-2和FGFR-1过表达，提示这些生长因子可能在促进人类涎腺肿瘤进展中起重要作用。
