兴奋的 T 细胞：Ca(v)1.4 通道的贡献和争议。

Excitable T cells: Ca(v)1.4 channel contributions and controversies.

机构信息

Department of Biophysics, Saarland University, 66421 Homburg, Germany.

出版信息

Immunity. 2011 Sep 23;35(3):315-7. doi: 10.1016/j.immuni.2011.09.001.

DOI:10.1016/j.immuni.2011.09.001

PMID:21943485

Abstract

Store-operated CRAC channels encoded by the Orai genes mediate calcium entry in T cells. In this issue of Immunity, Omilusik et al. (2011) record Ca(V)1.4-mediated voltage-gated calcium currents in T cells and address their role for T cell development and function.

摘要

Orai 基因编码的储存操纵型钙释放激活钙通道（Store-operated CRAC channels）介导 T 细胞中的钙离子内流。在本期《免疫》杂志中，Omilusik 等人（2011）记录了 T 细胞中的 Ca(V)1.4 介导的电压门控钙电流，并探讨了其在 T 细胞发育和功能中的作用。