Paris A, Dib M, Rousselet M-C, Urban T, Tazi A, Gagnadoux F
Département de pneumologie, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 9, France.
Rev Mal Respir. 2011 Sep;28(7):928-32. doi: 10.1016/j.rmr.2011.06.002. Epub 2011 Jul 30.
Pulmonary Langerhans histiocytosis (PLH) is a rare disease due to the accumulation of Langerhans cells at the level of the bronchioles. These dendritic immunocytes form granulomata and destroy the wall of the airway. We report a case of PLH developing at the same time as Hodgkin's lymphoma in a young woman who smoked tobacco and cannabis. We observed a complete remission of the PLH lesions parallel to the remission of the Hodgkin's lymphoma after chemotherapy, in the absence of any change in the consumption of tobacco and cannabis. This observation leads us to discuss the potential relationships between PLH on one hand, and smoking, the lymphoma and its treatment on the other.
肺朗格汉斯细胞组织细胞增多症（PLH）是一种罕见疾病，由于朗格汉斯细胞在细支气管水平积聚所致。这些树突状免疫细胞形成肉芽肿并破坏气道壁。我们报告一例年轻女性同时发生PLH和霍奇金淋巴瘤的病例，该女性有吸烟和吸食大麻史。我们观察到化疗后PLH病变完全缓解，同时霍奇金淋巴瘤也缓解，而烟草和大麻的使用量没有任何变化。这一观察结果促使我们讨论一方面PLH与另一方面吸烟、淋巴瘤及其治疗之间的潜在关系。
