Biomechanical Research Laboratory, Center of Engineering Mechanics, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing, PR China.
Comput Biol Med. 2011 Nov;41(11):1014-21. doi: 10.1016/j.compbiomed.2011.08.010. Epub 2011 Sep 23.
Studies showed that vascular diseases were prone to occur in curved arteries. In this paper, biomechanical behaviors of curved artery with flexible wall subjected to physiological flow were presented. Fluid-structure interaction effect was considered. The Von Mises stress variation and distribution patterns, the influence of artery curvature and flexibility on peak wall Von Mises stress, diameter change and cross sectional shape variation of the curved artery in the cardiac cycle were studied in detail. We believe that the findings may provide important implications for individualized treatment for patients with cardiovascular disease.
研究表明,血管疾病容易在弯曲的动脉中发生。本文提出了一种考虑流固耦合效应的柔性血管壁弯曲动脉的生物力学行为。详细研究了血管弯曲和弹性对峰值壁 Von Mises 应力、心动周期中弯曲动脉直径变化和横截面形状变化的影响。我们相信,这些发现可能为心血管疾病患者的个体化治疗提供重要启示。