循环内皮祖细胞与冠状动脉侧支形成的关系。
The association between circulating endothelial progenitor cells and coronary collateral formation.
机构信息
Department of Cardiology, Hacettepe University, Ankara, Turkey.
出版信息
Atherosclerosis. 2011 Dec;219(2):851-4. doi: 10.1016/j.atherosclerosis.2011.08.045. Epub 2011 Sep 6.
AIM
We investigated the relationship between coronary collateral formation and circulating endothelial progenitor cells (EPC) in patients undergoing coronary angiography.
METHODS AND RESULTS
Circulating CD133(+)/34(+) and CD34(+)/KDR(+) EPCs were determined in 68 patients (normal coronary vessels in 24 patients and coronary artery disease (CAD) in 44 patients) (age: 58.7 ± 10.1, 64.7% male). Circulating EPCs were higher among patients with normal coronary vessels compared to patients with CAD for CD133(+)/34(+) (p < 0.05) and CD34(+)/KDR(+) cells (p < 0.05). The number of EPCs were significantly greater in patients with good coronary collateral formation (p < 0.05). EPC count was independent predictor for coronary collateral formation after adjustment for other cardiovascular risk factors and extent of CAD (p = 0.037).
CONCLUSION
In patients with severe coronary stenosis, those with increased circulating EPCs had better collateral formation compared to those with lower EPC counts. Our findings implicate that in addition to presence of critical stenosis, intact response of bone marrow is necessary for collateral formation in CAD.
目的
我们研究了行冠状动脉造影患者的冠状动脉侧支循环形成与循环内皮祖细胞（EPC）之间的关系。
方法和结果
在 68 例患者（24 例正常冠状动脉患者和 44 例冠心病（CAD）患者）（年龄：58.7 ± 10.1，64.7%为男性）中测定了循环 CD133(+)/34(+)和 CD34(+)/KDR(+) EPC。与 CAD 患者相比，正常冠状动脉患者的循环 EPC 中 CD133(+)/34(+)（p < 0.05）和 CD34(+)/KDR(+)细胞（p < 0.05）更高。具有良好冠状动脉侧支循环形成的患者的 EPC 数量明显更高（p < 0.05）。校正其他心血管危险因素和 CAD 程度后，EPC 计数是冠状动脉侧支循环形成的独立预测因子（p = 0.037）。
结论
在严重冠状动脉狭窄的患者中，与 EPC 计数较低的患者相比，循环 EPC 增加的患者具有更好的侧支循环形成。我们的研究结果表明，除了存在严重狭窄外，骨髓的完整反应对于 CAD 的侧支循环形成也是必要的。
Zotero 插件