Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China.
Cardiovasc Diabetol. 2011 Dec 20;10:113. doi: 10.1186/1475-2840-10-113.
Patients with type 2 diabetes mellitus (DM) have increased risk of endothelial dysfunction and arterial stiffness. Levels of circulating endothelial progenitor cells (EPCs) are also reduced in hyperglycemic states. However, the relationships between glycemic control, levels of EPCs and arterial stiffness are unknown.
We measured circulating EPCs and brachial-ankle pulse wave velocity (baPWV) in 234 patients with type 2 DM and compared them with 121 age- and sex-matched controls.
Patients with DM had significantly lower circulating Log CD34/KDR+ and Log CD133/KDR+ EPC counts, and higher Log baPWV compared with controls (all P < 0.05). Among those 120/234 (51%) of DM patients with satisfactory glycemic control (defined by Hemoglobin A1c, HbA1c < 6.5%), they had significantly higher circulating Log CD34/KDR+ and Log CD133/KDR+ EPC counts, and lower Log baPWV compared with patients with poor glycemic control (all P < 0.05). The circulating levels of Log CD34/KDR+ EPC (r = -0.46, P < 0.001) and Log CD133/KDR+ EPC counts (r = -0.45, P < 0.001) were negatively correlated with Log baPWV. Whilst the level of HbA1c positively correlated with Log baPWV (r = 0.20, P < 0.05) and negatively correlated with circulating levels of Log CD34/KDR+ EPC (r = -0.40, P < 0.001) and Log CD133/KDR+ EPC (r = -0.41, P < 0.001). Multivariate analysis revealed that HbA1c, Log CD34/KDR+ and Log CD133/KDR+ EPC counts were independent predictors of Log baPWV (P < 0.05).
In patients with type 2 DM, the level of circulating EPCs and arterial stiffness were closely related to their glycemic control. Furthermore, DM patients with satisfactory glycemic control had higher levels of circulating EPCs and were associated with lower arterial stiffness.
2 型糖尿病（DM）患者内皮功能障碍和动脉僵硬的风险增加。循环内皮祖细胞（EPC）的水平在高血糖状态下也会降低。然而，血糖控制、EPC 水平和动脉僵硬之间的关系尚不清楚。
我们测量了 234 例 2 型 DM 患者和 121 例年龄和性别匹配的对照者的循环 EPC 和肱踝脉搏波速度（baPWV），并将其进行了比较。
与对照组相比，DM 患者的循环 Log CD34/KDR+和 Log CD133/KDR+EPC 计数明显较低，Log baPWV 较高（均 P<0.05）。在 120/234（51%）例血糖控制满意（定义为糖化血红蛋白，HbA1c<6.5%）的 DM 患者中，他们的循环 Log CD34/KDR+和 Log CD133/KDR+EPC 计数明显较高，Log baPWV 较低（均 P<0.05）。循环 Log CD34/KDR+EPC（r=-0.46，P<0.001）和 Log CD133/KDR+EPC 计数（r=-0.45，P<0.001）与 Log baPWV 呈负相关。而 HbA1c 水平与 Log baPWV 呈正相关（r=0.20，P<0.05），与循环 Log CD34/KDR+EPC（r=-0.40，P<0.001）和 Log CD133/KDR+EPC（r=-0.41，P<0.001）呈负相关。多变量分析显示，HbA1c、Log CD34/KDR+和 Log CD133/KDR+EPC 计数是 Log baPWV 的独立预测因子（P<0.05）。
在 2 型 DM 患者中，循环 EPC 水平和动脉僵硬与血糖控制密切相关。此外，血糖控制满意的 DM 患者循环 EPC 水平较高，与动脉僵硬程度较低有关。
