Stellato T A, Danziger L H, Gordon N, Hau T, Hull C C, Zollinger R M, Shuck J M
Department of Surgery, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Ohio 44106.
Am Surg. 1990 Apr;56(4):251-4.
A prospective, randomized double-blind study was undertaken to compare the efficacy of three prophylactic regimens (oral neomycin and erythromycin, intravenous cefoxitin, and a combination of both oral and intravenous antibiotics) in patients undergoing elective colorectal surgery. One hundred sixty-nine patients were randomized and 146 patients were evaluable. Septic complications occurred in 11.4 per cent of patients receiving oral antibiotics only, in 11.7 per cent of patients receiving intravenous cefoxitin alone, and in 7.8 per cent of patients receiving both oral and intravenous antibiotics. These differences were not statistically different. The greatest number of septic complications occurred in those patients with anastomotic disruptions. Two patients died (1.3%), both of whom had major anastomotic failures. There was no advantage between any of the groups in the incidence of wound infection (3.9-6.8%). Thus, no advantage could be identified in this study in the combination of oral and intravenous antibiotics in elective colorectal surgery.
进行了一项前瞻性随机双盲研究，以比较三种预防性治疗方案（口服新霉素和红霉素、静脉注射头孢西丁以及口服和静脉抗生素联合使用）在择期结直肠手术患者中的疗效。169例患者被随机分组，146例患者可进行评估。仅接受口服抗生素的患者中，11.4%发生了感染性并发症；仅接受静脉注射头孢西丁的患者中，11.7%发生了感染性并发症；接受口服和静脉抗生素联合使用的患者中，7.8%发生了感染性并发症。这些差异无统计学意义。感染性并发症发生率最高的是那些发生吻合口破裂的患者。两名患者死亡（1.3%），均发生了严重的吻合口失败。各组之间伤口感染发生率（3.9 - 6.8%）无差异。因此，在本研究中，择期结直肠手术中口服和静脉抗生素联合使用并无优势。
