Chan Wilson C W, Sze Kit Ling, Samartzis Dino, Leung Victor Y L, Chan Danny
Department of Biochemistry, The University of Hong Kong, LKS Faculty of Medicine, Pokfulam, Hong Kong SAR, China.
Orthop Clin North Am. 2011 Oct;42(4):447-64, vii. doi: 10.1016/j.ocl.2011.07.012.
The intervertebral disks along the spine provide motion and protection against mechanical loading. The 3 structural components, nucleus pulposus, annulus fibrosus, and cartilage endplate, function as a synergistic unit, though each has its own role. The cells within each of these components have distinct origins in development and morphology, producing specific extracellular matrix proteins that are organized into unique architectures fit for intervertebral disk function. This article focuses on various aspects of intervertebral disk biology and disruptions that could lead to diseases such as intervertebral disk degeneration.
脊柱上的椎间盘提供运动功能，并抵御机械负荷。椎间盘的三个结构组成部分，即髓核、纤维环和软骨终板，虽然各自发挥着独特作用，但作为一个协同单元发挥功能。这些组成部分中的每一个细胞在发育和形态上都有不同的起源，产生特定的细胞外基质蛋白，这些蛋白被组织成适合椎间盘功能的独特结构。本文重点关注椎间盘生物学的各个方面以及可能导致椎间盘退变等疾病的破坏因素。
