腰椎间盘退变的遗传学：技术、研究设计及危险因素
Genetics of lumbar disk degeneration: technology, study designs, and risk factors.
作者信息
Kao Patrick Yu-Ping, Chan Danny, Samartzis Dino, Sham Pak Chung, Song You-Qiang
机构信息
Department of Biochemistry, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong SAR, China.
出版信息
Orthop Clin North Am. 2011 Oct;42(4):479-86, vii. doi: 10.1016/j.ocl.2011.07.011.
Lumbar disk degeneration (LDD) is a common musculoskeletal condition. Genetic risk factors have been suggested to play a major role in its cause. This article reviews the main research strategies that have been used to study the genetics of LDD, and the genes that thus far have been identified to influence susceptibility to LDD. With the rapid progress in genomic technologies, further advances in the genetics of LDD are expected in the next few years.
腰椎间盘退变（LDD）是一种常见的肌肉骨骼疾病。遗传风险因素被认为在其病因中起主要作用。本文综述了用于研究LDD遗传学的主要研究策略，以及迄今为止已确定的影响LDD易感性的基因。随着基因组技术的快速发展，预计未来几年LDD遗传学将取得进一步进展。
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