Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK.
Semin Cancer Biol. 2011 Dec;21(6):397-404. doi: 10.1016/j.semcancer.2011.09.004. Epub 2011 Sep 16.
Autophagy, one of two major intracellular degradation pathways, plays a critical role in energy homeostasis and the quality control of macromolecules and intracellular organelles. Previous work has demonstrated the importance of autophagy in maintaining cellular fitness, both in healthy and stressful conditions, revealing the complex interplay between autophagy and other stress-responsive phenotypes. The complex outcomes of stress-responsive autophagy confer on it both pro- and anti-tumourigenic roles, depending on the cellular and environmental context. Furthermore, recent findings that functionally link autophagy to the tumour suppressor mechanism, cellular senescence, have revealed a new role of autophagy in cancer biology. In this review we summarise the current evidence on the relationship between autophagy and cancer, with a focus on its role in senescence.
自噬是两种主要的细胞内降解途径之一，在能量平衡和大分子及细胞内细胞器的质量控制中起着关键作用。以前的工作已经证明了自噬在维持细胞活力方面的重要性，无论是在健康还是应激条件下，揭示了自噬与其他应激反应表型之间的复杂相互作用。应激反应性自噬的复杂结果赋予其促肿瘤和抗肿瘤作用，这取决于细胞和环境的背景。此外，最近的研究发现，自噬与肿瘤抑制机制细胞衰老之间存在功能联系，揭示了自噬在癌症生物学中的新作用。在这篇综述中，我们总结了自噬与癌症之间关系的现有证据，重点介绍了自噬在衰老中的作用。
