Jiang Liangqian, Wang Yujuan, Yin Qifeng, Liu Guoxiang, Liu Huihui, Huang Yajing, Li Bing
Department of Genetics and Cell Biology, Basic medical college, 308 Ningxia Road, Qingdao University, Qingdao, China, 266071.
Basic medical college, 308 Ningxia Road, Qingdao University, Qingdao, China, 266071.
J Cancer. 2017 Sep 20;8(17):3416-3429. doi: 10.7150/jca.21058. eCollection 2017.
Phycocyanin isolated from marine organisms has the characteristics of high efficiency and low toxicity, and it can be used as a functional food. It has been reported that phycocyanin has anti-oxidative function, anti-inflammatory activity, anti-cancer function, immune enhancement function, liver and kidney protection pharmacological effects. Thus, phycocyanin has an important development and utilization as a potential drug, and phycocyanin has become a new hot spot in the field of drug research. So far, there are more and more studies have shown that phycocyanin has the anti-cancer effect, which can block the proliferation of cancer cells and kill cancer cells. Phycocyanin exerts anti-cancer activity by blocking tumor cell cell cycle, inducing tumor cell apoptosis and autophagy, thereby phycocyanin can serve as a promising anti-cancer agent. This review discusses the therapeutic use of phycocyanin and focuses on the latest advances of phycocyanin as a promising anti-cancer drug.
从海洋生物中分离出的藻蓝蛋白具有高效低毒的特点，可作为功能性食品。据报道，藻蓝蛋白具有抗氧化功能、抗炎活性、抗癌功能、免疫增强功能以及肝肾保护药理作用。因此，藻蓝蛋白作为一种潜在药物具有重要的开发利用价值，已成为药物研究领域的一个新热点。迄今为止，越来越多的研究表明藻蓝蛋白具有抗癌作用，能够阻断癌细胞的增殖并杀死癌细胞。藻蓝蛋白通过阻断肿瘤细胞周期、诱导肿瘤细胞凋亡和自噬发挥抗癌活性，因此可作为一种有前景的抗癌药物。本文综述了藻蓝蛋白的治疗用途，并重点关注其作为一种有前景的抗癌药物的最新进展。
