Barnard J A, Lyons R M, Moses H L
Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232.
Biochim Biophys Acta. 1990 Jun 1;1032(1):79-87. doi: 10.1016/0304-419x(90)90013-q.
The TGF beta family of polypeptide growth factors regulates a remarkable diversity of cellular functions, many of which are not directly associated with cell growth. The present review has summarized many of the recent studies that have just begun to conceptually integrate this expanding array of TGF beta functions into the context of a three-dimensional, multicellular organ or tissue, be it normal or diseased. This fascinating research strongly implicates TGF beta as a key modulator of a wide variety of important physiologic and pathophysiologic processes.
多肽生长因子的转化生长因子β（TGF-β）家族调节着多种多样的细胞功能，其中许多功能与细胞生长并无直接关联。本综述总结了许多近期研究，这些研究刚刚开始从概念上将这一系列不断扩展的TGF-β功能整合到三维多细胞器官或组织的背景中，无论该器官或组织是正常的还是患病的。这项引人入胜的研究有力地表明，TGF-β是多种重要生理和病理生理过程的关键调节因子。
