Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, United States.
Semin Cell Dev Biol. 2011 Dec;22(9):976-84. doi: 10.1016/j.semcdb.2011.09.009. Epub 2011 Sep 18.
The ETS family of transcription factors plays an essential role in controlling endothelial gene expression. Multiple members of the ETS family are expressed in the developing endothelium and evidence suggests that the proteins function, to some extent, redundantly. However, recent studies have demonstrated a crucial non-redundant role for ETV2, as a primary player in specification and differentiation of the endothelial lineage. Here, we review the contribution of ETS factors, and their partner proteins, to the regulation of embryonic vascular development.
ETS 转录因子家族在控制内皮细胞基因表达中起着至关重要的作用。ETS 家族的多个成员在内皮细胞发育中表达，并表明这些蛋白质在一定程度上具有冗余功能。然而，最近的研究表明，ETV2 在血管内皮谱系的特化和分化中起着至关重要的非冗余作用。在这里，我们回顾了 ETS 因子及其伴侣蛋白在胚胎血管发育调控中的作用。
