Department of Neurology, Keyo Medical Foundation, Keyo Geriatric Hospital, Anyang, Republic of Korea.
Alzheimer Dis Assoc Disord. 2012 Apr-Jun;26(2):191-3. doi: 10.1097/WAD.0b013e318231a896.
To describe a patient with prodromal dementia with Lewy bodies (DLB) manifesting as sertraline-induced parkinsonism.
Case report.
Tertiary referral center.
A 75-year-old man who initially presented with anxiety and depression along with mild cognitive impairment, later developed drug-induced parkinsonism because of sertraline treatment, and eventually showed symptoms and signs of probable DLB.
Sertraline treatment for depression.
: Clinical examination, magnetic resonance imaging, neuropsychologic test, and cardiac I-metaiodobenzylguanidine scintigraphy.
His parkinsonian symptoms, which became apparent after sertraline therapy, improved markedly after the discontinuation of the drug. When he started taking sertraline, he had no dementia but had mild cognitive impairment. However, he eventually showed most of the symptoms and signs to indicate probable DLB.
To our knowledge, there has been no report of sertraline-induced or aggravated parkinsonian motor symptoms in DLB patients. Our patient had a short period with neither dementia nor parkinsonism during the early stage of his illness, and this period might have been regarded as the preclinical stage of DLB in the natural course of his illness.
描述一例以左旋体痴呆（DLB）前驱期为表现的、由舍曲林引起的帕金森病患者。
病例报告。
三级转诊中心。
一名 75 岁男性，最初表现为焦虑和抑郁，伴有轻度认知障碍，后来因舍曲林治疗而出现药物诱导性帕金森病，最终出现可能的 DLB 的症状和体征。
舍曲林治疗抑郁。
临床检查、磁共振成像、神经心理学测试和心脏 I-间碘苄胍闪烁显像。
他的帕金森病症状在舍曲林治疗后明显出现，停药后明显改善。当他开始服用舍曲林时，他没有痴呆，但有轻度认知障碍。然而，他最终表现出大多数的症状和体征，表明可能患有 DLB。
据我们所知，在 DLB 患者中，没有舍曲林引起或加重帕金森运动症状的报告。我们的患者在疾病早期既没有痴呆也没有帕金森病，这段时间可能被认为是他疾病自然病程中 DLB 的临床前期。
