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三氯苯达唑保护酵母和哺乳动物细胞免受氧化应激：一种潜在神经保护化合物的鉴定。

Triclabendazole protects yeast and mammalian cells from oxidative stress: identification of a potential neuroprotective compound.

机构信息

Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.

出版信息

Biochem Biophys Res Commun. 2011 Oct 14;414(1):205-8. doi: 10.1016/j.bbrc.2011.09.057. Epub 2011 Sep 16.

DOI:10.1016/j.bbrc.2011.09.057
PMID:21946065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3195900/
Abstract

The Prestwick and NIH chemical libraries were screened for drugs that protect baker's yeast from sugar-induced cell death (SICD). SICD is triggered when stationary-phase yeast cells are transferred from spent rich medium into water with 2% glucose and no other nutrients. The rapid, apoptotic cell death occurs because reactive oxygen species (ROS) accumulate. We found that triclabendazole, which is used to treat liver flukes in cattle and man, partially protects against SICD. Characterization of triclabendazole revealed that it also protects yeast cells from death induced by the Parkinson's disease-related protein alpha-synuclein (α-syn), which is known to induce the accumulation of ROS.

摘要

普雷斯威克和 NIH 化学文库被筛选出能够保护面包酵母免受糖诱导的细胞死亡（SICD）的药物。当静止期酵母细胞从耗尽的丰富培养基转移到含有 2%葡萄糖和没有其他营养物质的水中时，就会触发 SICD。快速的细胞凋亡发生是因为活性氧（ROS）积累。我们发现，三氯苯达唑，用于治疗牛和人类的肝吸虫，部分保护酵母细胞免受与帕金森病相关的蛋白质α-突触核蛋白（α-syn）诱导的 SICD。对三氯苯达唑的特征分析表明，它还可以保护酵母细胞免受帕金森病相关蛋白α-突触核蛋白（α-syn）诱导的死亡，已知α-突触核蛋白会诱导 ROS 的积累。

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本文引用的文献

1
Alpha-synuclein functions in the nucleus to protect against hydroxyurea-induced replication stress in yeast.α-突触核蛋白在细胞核中发挥作用，以防止酵母中羟基脲诱导的复制应激。
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Phosphate and succinate use different mechanisms to inhibit sugar-induced cell death in yeast: insight into the Crabtree effect.磷酸盐和琥珀酸盐通过不同的机制抑制酵母中糖诱导的细胞死亡：对 Crabtree 效应的深入了解。
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Functional mitochondria are required for alpha-synuclein toxicity in aging yeast.功能性线粒体是衰老酵母中α-突触核蛋白毒性所必需的。
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Yeast cells lacking the CIT1-encoded mitochondrial citrate synthase are hypersusceptible to heat- or aging-induced apoptosis.缺乏CIT1编码的线粒体柠檬酸合酶的酵母细胞对热诱导或衰老诱导的细胞凋亡高度敏感。
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Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease.热休克可预防帕金森病酵母模型中α-突触核蛋白诱导的细胞凋亡。
J Mol Biol. 2005 Sep 2;351(5):1081-100. doi: 10.1016/j.jmb.2005.06.060.
8
Yeast cells provide insight into alpha-synuclein biology and pathobiology.酵母细胞为α-突触核蛋白的生物学和病理生物学研究提供了线索。
Science. 2003 Dec 5;302(5651):1772-5. doi: 10.1126/science.1090439.
9
Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein.可增强突变型亨廷顿蛋白片段或α-突触核蛋白毒性的酵母基因。
Science. 2003 Dec 5;302(5651):1769-72. doi: 10.1126/science.1090389.
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