Tanaka Koji, Koga Masatoshi, Miyashita Fumio, Kajimoto Katsufumi, Matsushige Toshinori, Sato Tetsu, Ishibashi-Ueda Hatsue, Iihara Koji, Toyoda Kazunori
Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center.
Rinsho Shinkeigaku. 2011 Sep;51(9):706-9. doi: 10.5692/clinicalneurol.51.706.
A 66-year old hypertensive man having a prostate cancer was admitted to our hospital with sudden onset right hemiparesis. On admission, he showed left hemiplegia, hypesthesia, right limb ataxia, and dysarthria. The NIHSS score was 16. Diffusion weighted magnetic resonance imaging showed an acute infarct in the middle pons and magnetic resonance angiography (MRA) revealed basilar artery (BA) occlusion. Carotid Doppler ultrasonography showed distal occlusion pattern of the bilateral vertebral artery. He was treated with intravenous rt-PA at 116 minutes after symptom onset. One hour later, his symptom was not improved and BA was still occluded on follow-up MRA. Therefore, we performed mechanical thrombectomy with Merci(®) Retrieval System. At 323 minutes after onset, BA was successfully recanalized and NIHSS score decreased to 4 without hemorrhagic complication. Medication of oral warfarin was started on day 19 because paroxysmal atrial fibrillation was detected by electrocardiogram. The retrieved thrombus was pathologically diagnosed as a organizing mixed thrombus probable cardiac origin. On day 27, he was discharged home without any neurological deficit. Additional thrombectomy with Merci(®) Retrieval System is a promising treatment strategy for BA occlusion which is resistant to intravenous rt-PA thrombolysis.
一名66岁患有前列腺癌的高血压男性因突发右侧偏瘫入住我院。入院时,他表现为左侧偏瘫、感觉减退、右侧肢体共济失调和构音障碍。美国国立卫生研究院卒中量表(NIHSS)评分为16分。弥散加权磁共振成像显示脑桥中部急性梗死,磁共振血管造影(MRA)显示基底动脉(BA)闭塞。颈动脉多普勒超声显示双侧椎动脉远端闭塞型。症状发作116分钟后,他接受了静脉注射重组组织型纤溶酶原激活剂(rt-PA)治疗。1小时后,他的症状未改善,随访MRA显示BA仍闭塞。因此,我们使用Merci(®)取栓系统进行了机械取栓。发作323分钟时,BA成功再通,NIHSS评分降至4分,无出血并发症。由于心电图检测到阵发性心房颤动,在第19天开始口服华法林治疗。取出的血栓经病理诊断为可能源于心脏的机化混合血栓。第27天,他出院回家,无任何神经功能缺损。对于对静脉rt-PA溶栓有抵抗的BA闭塞,使用Merci(®)取栓系统进行额外的取栓是一种有前景的治疗策略。