Malinin Nikolay L, West Xiaoxia Z, Byzova Tatiana V
Department of Molecular Cardiology, J.J. Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Aging (Albany NY). 2011 Sep;3(9):906-10. doi: 10.18632/aging.100385.
Multiple biological consequences of oxidative stress are known to contribute to aging and aging-related pathologies. It was recently shown that (carboxyalkyl)pyrroles (CAPs), the end products of phospholipid oxidation serve as a novel class of endogenous ligands for Toll-like receptors (TLRs) and promote the process of angiogenesis. In this review, we discuss implications of these findings in the context of age-related pathologies, including tumorigenesis. Accumulation of oxidation products in tissues of aging organisms might create conditions for uncontrolled pathological angiogenesis as seen in patients with age related macular degeneration. CAPs and their receptors, TLRs might also promote the progression of atherosclerotic lesions. Importantly, besides their role in a number of pathologies, oxidative products of phospholipids contribute to tissue repair processes thereby antagonizing the destructive effects of oxidation.
氧化应激的多种生物学后果已知会导致衰老及与衰老相关的病理状况。最近有研究表明，磷脂氧化的终产物（羧烷基）吡咯（CAPs）作为一类新型的Toll样受体（TLRs）内源性配体，可促进血管生成过程。在本综述中，我们将在与年龄相关的病理状况（包括肿瘤发生）的背景下讨论这些发现的意义。衰老生物体组织中氧化产物的积累可能会为不受控制的病理性血管生成创造条件，如年龄相关性黄斑变性患者所见。CAPs及其受体TLRs也可能促进动脉粥样硬化病变的进展。重要的是，除了在多种病理状况中的作用外，磷脂的氧化产物有助于组织修复过程，从而对抗氧化的破坏作用。
