氧化磷脂的应激和抗炎特性。

Hormetic and anti-inflammatory properties of oxidized phospholipids.

机构信息

Institute of Pharmaceutical Sciences, University of Graz, Humboldtstrasse 46/III, A-8010 Graz, Austria.

Department of Biomedicine, University Hospital Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland.

出版信息

Mol Aspects Med. 2016 Jun;49:78-90. doi: 10.1016/j.mam.2016.02.003. Epub 2016 Mar 3.

DOI:10.1016/j.mam.2016.02.003

PMID:26948981

Abstract

Oxidized phospholipids are generally recognized as deleterious factors involved in disease pathogenesis. This review summarizes the data suggesting that under certain biological conditions the opposite is correct, namely that OxPLs can also induce protective effects. Examples that are discussed in the review include upregulation of antioxidant genes, inhibition of inflammatory signaling pathways through Nrf2-dependent and -independent mechanisms, antagonism of Toll-like receptors, immuno-modulating and immuno-suppressive action of OxPLs in adaptive immunity and autoimmune disease, activation of PPARs known for their anti-inflammatory action, as well as protective action against lung edema in acute lung inflammation. The data support the notion that oxidation of phospholipids provides a negative feedback preventing damage to host tissues due to uncontrolled inflammation and oxidative stress.

摘要

氧化磷脂通常被认为是参与疾病发病机制的有害因素。这篇综述总结了一些数据，表明在某些生物条件下，情况正好相反，即 OxPLs 也可以诱导保护作用。综述中讨论的例子包括抗氧化基因的上调、通过 Nrf2 依赖和非依赖机制抑制炎症信号通路、Toll 样受体的拮抗作用、适应性免疫和自身免疫性疾病中 OxPLs 的免疫调节和免疫抑制作用、已知具有抗炎作用的过氧化物酶体增殖物激活受体 (PPARs) 的激活，以及对抗急性肺炎症性肺水肿的保护作用。这些数据支持这样一种观点，即磷脂的氧化提供了一种负反馈机制，防止由于不受控制的炎症和氧化应激对宿主组织造成损害。