Petersson Fredrik
Department of Pathology, National University Hospital, Singapore.
Am J Dermatopathol. 2011 Oct;33(7):742-4. doi: 10.1097/DAD.0b013e318206f66a.
An unusual variant of dendritic cell neurofibroma is reported. In contrast to previous cases, the formation of pseudorosettes was lacking. The tumor was located on the anterior aspect of the thigh in a previously healthy 71-year-old woman with no evidence of neurofibromatosis. The tumor was composed of type-1 and type-2 cells, which were immunoreactive for S-100 protein and CD57. The granulomatous appearance was due to the zonal accumulation of CD34-positive dendritic cells and type-1 cells in a serpiginous fashion surrounding large areas with lesser cellularity featuring type-2 cells with scattered type-1 cells arranged in a haphazard fashion. Intralesional small neurites positive for neurofilament and perilesional perineural cells positive for epithelial membrane antigen were documented immunohistochemically.
报道了一种不寻常的树突状细胞神经纤维瘤变体。与先前病例不同的是，缺乏假菊形团的形成。该肿瘤位于一名71岁既往健康、无神经纤维瘤病证据的女性大腿前侧。肿瘤由1型和2型细胞组成，这些细胞对S-100蛋白和CD57呈免疫反应性。肉芽肿样外观是由于CD34阳性树突状细胞和1型细胞呈匐行状带状聚集，围绕细胞较少的大片区域，这些区域以杂乱方式排列着散在1型细胞的2型细胞。免疫组化显示瘤内神经丝阳性的小神经突和瘤周上皮膜抗原阳性的神经周细胞。
